Heritability and linkage analysis of appendicitis utilizing age at onset.
نویسندگان
چکیده
Appendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3.
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عنوان ژورنال:
- Twin research and human genetics : the official journal of the International Society for Twin Studies
دوره 12 2 شماره
صفحات -
تاریخ انتشار 2009